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Using a mouse-adapted LAIV against influenza A (H3N2) virus carrying the same mutations as the human FluMist vaccine, we find that LAIV vaccination reverses normal bacterial clearance from the nasopharynx and significantly increases bacterial carriage densities of the clinically important bacterial pathogens Streptococcus pneumoniae (serotypes 1...
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Intranasal powder live attenuated influenza vaccine is ... - Nature
Recently, two randomized controlled trials (RCTs) assessing Russian-backbone trivalent LAIV in children reported contradictory results; vaccine efficacy varied between Bangladesh (41 %) and Senegal (0.0 %) against all influenza viral strains. Prior to 2013, Ann Arbor-based LAIV demonstrated superior efficacy as compared to IIV.
Defining the root cause of reduced H1N1 live attenuated ... - Nature
Menurut Organisasi Kesehatan Dunia , ada dua jenis vaksin influenza yang tersedia secara luas: yakni vaksin influenza yang dilemahkan (IIV) dan vaksin influenza hidup yang dilemahkan (LAIV). Secara tradisional, vaksin influenza (IIV dan LAIV) telah diproduksi untuk melindungi dari 3 virus influenza musiman yang berbeda (juga disebut vaksin ...
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